Feed industry as a manufacturing industry, efficiency, cost, and quality are the eternal themes. Antibiotic-free, food-saving, low pollution, low energy consumption, and high output are the general trend. A host of new technologies.
01 Feed formic acid
The common name of formic acid is formic acid, its chemical formula is HCOOH, and its molecular weight is 46.03. It is the simplest carboxylic acid. Very acidic and corrosive.
1.1 Formic acid has the advantages of strong hydrogen supply capacity (pKa is 3.75), strong bactericidal ability, wide antibacterial spectrum, non-toxic and no residue, and is not easy to produce drug resistance.
1.2 Disadvantages of formic acid, such as strong volatility, strong corrosion, and easy reaction with feed components.
1.3 Key words of formic acid innovation technology: capsular adsorption, formic acid embedding, full liquefaction, unique polyphenol, polyphenol scaling, half-coated slow release, buffer, slow release, modification.
02 Feed phosphoric acid
Phosphoric acid or orthophosphoric acid is a common inorganic acid. It is a ternary medium-strong acid. It is ionized in three steps. It is not easy to volatilize and decompose. Its pKa1 is 2.12, pKa2 is 7.20, and pKa3 is 12.36.
Key words of phosphoric acid innovative technology: patented coating process, reducing phosphoric acid reactivity, no gas production, no bag expansion, reduced reaction heat generation, mixed with formic acid formate, less irritating odor.
03 Feed benzoic acid
Benzoic acid is an aromatic acid organic compound and the simplest aromatic acid.
3.1 The application of benzoic acid in animals faces the following problems: ① In pigs, 85% is metabolized into hippuric acid by the liver and excreted through urine. ②In chickens, 54% is metabolized to orniuric acid, and 21% is metabolized to hippuric acid. ③It is easy to ionize quickly under the condition of pH 6 or above. ④The addition amount is higher than 5 kg, which will affect the palatability of the feed. ⑤Rapid rise in blood sugar concentration has an impact on food intake. ⑥Other cumulative adverse reactions.
3.2 Key words of benzoic acid innovative technology: high-efficiency granulation, Liuhua coating, cold spray coating, reducing blood penetration, slow release, and ensuring more molecular benzoic acid.
04 Traditional Chinese medicine for livestock and poultry
The theory of yin and yang and five elements in traditional Chinese medicine, the theory of meridian flow, the core idea of traditional Chinese medicine is to prevent diseases, "prevent diseases before they occur, and prevent diseases from becoming worse."
There are more than four great inventions in China, and the biggest invention is traditional Chinese medicine.
Using 117 kinds of natural plants, we have developed a new non-antibiotic functional feed to solve the current problems in the breeding industry!
Inheritance does not follow the past, and innovation does not depart from the tradition. Inherit good prescriptions, inherit good medicinal materials, inherit + innovate good craftsmanship.
Key words of innovation in traditional Chinese medicine (animal application): traditional Chinese medicine application of natural plants, compound dynamic extraction of all ingredients.
05 Feed trace elements
5.1 Advantages of amino acid chelate (complex) compounds: stable structure, easy digestion and absorption, high biological potency, anti-interference, and environment-friendly.
5.2 Organic iron. ① Dipeptide iron, compared with ferrous sulfate, can significantly increase the number of live piglets and newborn litter weight of sows, and reduce the number of stillbirths, mummies and weak piglets. ②Iron oligobisaccharide significantly increased the serum iron level and GLU level of farrowing sows (P<0.05), and at the same time increased the serum iron level of piglets, and increased serum ALP, IgM, IgG and other proteins. ③ Adding organic compound iron to sows during lactation period can significantly increase the weaning weight by 13.46%, significantly increase the litter weight gain by 10.18%, and significantly increase the daily gain by 14.56%. ④ Ferrous fumarate/iron glycinate significantly reduced the feed-to-weight ratio of weaned piglets.
5.3 Zincified polysaccharides. Compared with commonly used antibiotics, zincated polysaccharides significantly improved the piglets' digestibility, reduced the rate of diarrhea, and promoted their growth to a certain extent.
5.4 Functional trace element complexes have positive effects on pork quality, chicken quality, and laying hen performance.
5.5 Innovation keywords: functional trace element amino acid complexes, functional trace element small peptide/protein complexes, functional trace element polysaccharide complexes, functional trace element oligosaccharide complexes, multi-component complexes of trace elements Combined technology, polysaccharide selenium, nano-selenium.
06 Feed trace elements
6.1 Pay attention to new forms of iodine and selenium sources, and explore their functional effects beyond nutritional effects. Whether it is iodine or iodophor, they are highly irritating and are only for external use and cannot be added to feed.
6.2 The new form of iodine (CHE-I) is based on organic iodine, and after special processing, it has heat stability and storage stability in feed. The use of CHE-I (10ppm) in the feed is beneficial to the intestinal villi and can reduce the damage of the intestinal villi.
6.3 CHE-I in duck test:
①When the dosage of CHE-I is low (1-4ppm), it has no significant effect on the cecum Firmicutes, but when the dosage is high (8ppm ppm), it can reduce the number of the cecum Firmicutes, and has the effect of inhibiting bacteria.
②Compared with colistin 40ppm, CHE-I significantly increased the overall body weight and 1-14d daily gain of meat ducks, and 4-8ppm significantly decreased the whole-process feed-to-meat ratio by 0.09 (1.87→1.78).
③ Adding different levels of CHE-I had statistical differences in energy conversion, nucleotide transport and metabolism, post-translational modification, and protein turnover.
④ With the increase of CHE-I supplementation level, the contents of acetic acid and propionic acid in the cecal contents of meat ducks also gradually increased.
6.4 nano-selenium has strong anti-oxidation, anti-digestive tract damage, high safety, good stability, etc., and intestinal health has a significant relationship with antioxidant capacity.
6.5 The test results of adding organic iodine-nano-selenium compound (Aixijia) to the feed.
①It has the functions of strong anti-oxidation, high safety, and curing intestinal barrier.
② The addition of 0.05% of Aciga feed can significantly improve the daily gain and feed-to-meat ratio of broilers.
③The addition of 0.1% Aciga feed can significantly reduce the rate of diarrhea (ideal litter index) and mortality.
6.6 Key words of innovation: special process organic iodine, nano-selenium compound, solidified intestinal barrier.
07 Feed Antimicrobial Peptides
Initially, when people were studying the immune mechanism of the North American cerevisiae, they found that after the diapause pupae were induced by external stimuli, the hemolymph produced polypeptide substances with antibacterial effect. This kind of antibacterial polypeptide was named Cecropins. In the years after 1980, people successively discovered and isolated polypeptides with antibacterial activity from bacteria, fungi, amphibians, insects, higher plants, mammals and even humans. Because this kind of active peptides has broad-spectrum and high-efficiency bactericidal activity against bacteria, it is named "antibacterialpepitides, ABP", which is translated into antibacterial peptides in Chinese.
7.1 Scientific evaluation of antimicrobial peptides: clear ingredients, clear structure, and scientific detection methods (identification of antibacterial activity, immune activity). Liquid phase is the most practical method for the detection of antimicrobial peptides, and it is also the core technology for stable quality.
7.2 The MIC value is the only indicator to determine the usage amount, and the actual usage amount should be slightly greater than the MIC value.
7.3 Enterobacitracin is currently one of the more comprehensive and in-depth research on antibacterial peptides in the world, and there are also subtilisin and so on.
7.4 The principle of replacing antibiotics is to replace with the same mechanism, and to replace with the same effect.
08 Pig farm liquid feeding
8.1 Liquid feeding is widely used in Europe. With the banning of antibiotics more common, there are four advantages in general: cost reduction, efficiency increase, health and environmental protection. It can improve production performance, improve nutrient utilization, improve the development of the digestive tract and increase the activity of digestive enzymes.
8.2 Liquid feed form: ① Newborn and weaned piglets generally use liquid milk + creep feed; ② The integrated water-feed ratio of nursery and fattening = 2.5:1-3:1. ③ Reserve, empty pregnant and pregnant sows: liquid feeding, water-feed ratio = 3:1. ④ Lactating sows: liquid feeding, water-feed ratio = 2.5-3:1.
8.3 There are three common processes for liquid fermented feed: natural fermentation, directed fermentation, and grain-only fermentation.
8.4 Liquid feeding issues to be further resolved:
① Systematic evaluation of liquid feeding effects of different pig breeds and herds.
②Suitable for processing and evaluation of different raw materials.
③ Improvement of evaluation indicators and system of bio-fermented feed.
9 β-glucan for livestock and poultry
9.1 What is immune training?
The currently generally accepted view that only adaptive immunity can establish immune memory is being challenged. More and more studies have shown that innate immune cells such as monocytes, macrophages and natural killer (NK) cells can generate a new immune response with non-specific memory under the stimulation of exogenous infection to deal with secondary Homologous or heterologous infection, this process is called trained immunity. It is characterized by the host's hyperresponsive, nonspecific immune "memory" for reinfection; moreover, this process does not rely on classical T and B cell adaptive immunity , but driven by epigenetic modifications and immunometabolism. The proposal of training immunity is an extension of the principle of immunology, which provides a new direction for the study of immunological mechanisms (Zhang Xu, et al. 2019).
Training immunity is a unique characteristic of beta-glucan, but not all sources of beta-glucan are created equal.
New technology keywords: high concentration, yeast purification, β-1,3-1,6-D-glucan.
10 Feed fat predigestion
10.1 What is predigestion?
Under the in vitro conditions of animals, by simulating the conditions required for digestion in animals, feed or feed components are decomposed or degraded into small molecules or small particles through fermentation, enzymatic hydrolysis, emulsification and other processes. Its purpose is to improve feed components and improve feed digestion and utilization.
10.2 The necessity of fat predigestion. It is a common practice to add a large amount of fat (generally about 5%-8%) to meat and poultry feed, but affected by many factors, incomplete digestion of fat will lead to waste and even cause health problems, emulsification in the body (adding bile acid, phospholipid, etc. to the feed) There are defects of increased energy consumption and incomplete emulsification, so in vitro pre-digestion has been paid more and more attention.
10.3 Essence of oil predigestion: to turn ordinary oil into predigested oil and increase the number of single and mixed micelles in the body.
10.4 How to achieve fat pre-digestion? The system of pre-digester + oil + water, under the action of pre-digestion equipment (3000 rpm homogeneous), turns the fat particles of oil into emulsified fat particles.
10.5 Quality evaluation indicators of predigested oil: ① HLB value 12-14; ② oil particle size; ③ chyle maintenance time; ④ fat oxidation rancidity degree. However, Lizhimei is excellent in all indicators of quality evaluation after pre-digested oil.
10.6 Grease predigester --- Lizhimei, the test conclusions in meat ducks:
①Compared with the direct addition group and the commercial emulsifier group (internal digestion), the effect of Lizhimei predigested oil was the best, followed by the Lizhimei direct addition group. Whether the emulsifier is directly added or pre-digested fat, the effect of duck oil is better than that of mixed oil
②Compared with undigested fat, adding predigested fat to the basic diet can significantly increase (P<0.05) the weight of meat ducks, and the feed-to-meat ratio can be improved by 0.06.
③Compared with the 6% oil group, the predigested oil saves more than 0.6% of feed oil consumption, which can save more than 50kcal/kgME.
10.7 Trial of Lizhimei in broiler chickens: Add Lizhimei, reduce the amount of fat by 10%, and have no significant impact on production performance.
10.8 Application of Lizhimei: ①Lizhimei Type 1: Used for commercial meat and poultry feed, it has three functions of oil pre-digestion + mildew prevention + water retention, and the cost of feed can be reduced by 58.1 yuan per ton. ② Lizhimei-Ⅱ: It is used for one-stop and post-spraying of oil, with the effect of oil pre-digestion, and the cost of feed can be reduced by 20.5 yuan per ton.
10.9 Lizhimei, an oil pre-digester: supporting professional equipment SMIMOS.
11 Targeted Degradation of Deoxynivalenol
11.1 The removal efficiency of deoxynivalenol for vomitoxin is very low, but vomitoxin is very harmful, especially for pigs and young animals.
11.2 New technology for targeted degradation of vomitoxin:
① Utilize iron-based and manganese-based nanozyme targeting;
②Under certain conditions of temperature and humidity (conditioning and granulation), the toxic sites such as DON epoxy ring can be quickly destroyed within 1 minute, and DON can be degraded during the feed processing process, and the toxin degradation rate can reach 50% or higher.
③Effect evaluation is very convenient and fast, and can be evaluated by comparative testing before and after feed conditioning and granulation.
④Used in corn, wheat by-products and pellet feed to degrade vomitoxin
11.3 Key words of new technology:
M (method) --- Targeted degradation of DON
A (site) --- Degradation of DON in vitro
S (stable) --- 120 ℃ tolerance
T (time) --- 1 minute to degrade DON
E (efficiency)---50% degradation rate
R (experience)---immediate and convenient experience
12 Mycotoxin degradation
12.1 Degradation mechanism of aflatoxin
The decomposing enzyme acts on the difuran ring 8,9 ene ether bond of the toxic group of aflatoxin B1 to decompose it into non-toxic substances.
12.2 Degradation mechanism of vomitoxin
The hydroxyl group at the 3-position of DON carbon is first oxidized to form 3-keto-DON, which reduces the toxicity by 10 times, and then undergoes a reduction reaction to form 3-isomeric-DON, which reduces the toxicity by 1182 times.
12.3 Evaluation: ① feeding test; ② emergency use with typical symptoms; ③ short-term in vivo evaluation; ④ laboratory evaluation (in vitro simulation)